Department of Dermatology & Dermatosurgery, Skinnocence: The Skin Clinic & Research Center, Gurugram, India.
J Cosmet Dermatol. 2021 Jul;20(7):2141-2147. doi: 10.1111/jocd.14215. Epub 2021 May 25.
Treatment-refractory lesions of vitiligo and psoriasis are typically associated with significant psychological morbidity. Although narrowband-ultraviolet B (NB-UVB) phototherapy remains one of the safest and effective treatment modalities, the cost and logistics related to the access and high cost of therapy delivered artificially via devices/chambers become highly restrictive. The use of topical Photocil®, a novel topical band-pass filter cream (TBFC), that selectively filters solar radiation, biasing toward delivery of 311-313 nm (action spectrum of NB-UVB) to the treated lesions, following the exposure of TBFC-smeared lesions to natural sunlight offsets many aforementioned limitations of artificial phototherapy. The non-inferior efficacy of Photocil® as an alternative to artificial NB-UVB has recently been reported in patients with lighter skin phototypes (SPT) with non-segmental vitiligo and psoriasis.
To demonstrate the high efficacy-cum-safety of the novel approach in repigmenting treatment-refractory segmental vitiligo (SV) in an adult man with SPT-V and discuss the essentials of successful administration of NB-UVB using this approach.
The baseline clinical details and therapeutic outcome of 12-week protocol of TBFC-assisted NB-UVB (with details of step-by-step administration including precautions) in SV of the aforementioned patient are discussed.
Up to 75% repigmentation without any remarkable adverse effects was noted with persistent efficacy over the next 12 weeks.
The device-free home-based TBFC-assisted NB-UVB delivery using natural sunlight offers a viable, convenient, and cost-effective alternative to artificial phototherapy for successful treatment of vitiligo; with its utility proven even in SV that too in individual(s) with darker SPT.
白癜风和银屑病的难治性病变通常与明显的心理病态相关。尽管窄谱中波紫外线（NB-UVB）光疗仍然是最安全和有效的治疗方式之一，但由于设备/室提供的治疗的可及性和高成本相关的成本和后勤限制变得非常严格。使用新型局部带通滤光乳膏（TBFC） Photocil®，它选择性地过滤太阳辐射，偏向于将 311-313nm（NB-UVB 的作用光谱）递送至受治疗的病变，在 TBFC 涂抹的病变暴露于自然光下后，这可以抵消许多上述人工光疗的限制。最近已经报道了 Photocil®作为人工 NB-UVB 的替代物在非节段性白癜风和银屑病的浅色皮肤光型（SPT）患者中的非劣效性。
证明这种新型方法在治疗成人 SPT-V 的难治性节段性白癜风（SV）中具有高疗效和安全性，并讨论使用这种方法成功进行 NB-UVB 治疗的要点。
讨论了上述患者的 12 周 TBFC 辅助 NB-UVB 治疗方案（包括逐步管理的详细信息，包括预防措施）的基线临床细节和治疗结果。
在接下来的 12 周中，观察到高达 75%的复色，没有任何明显的不良反应，并且疗效持续。
使用自然光的无设备家庭 TBFC 辅助 NB-UVB 输送提供了一种可行、方便且具有成本效益的替代人工光疗的方法，用于成功治疗白癜风；即使在深色 SPT 的个体中也证明了其在 SV 中的效用。
