Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany; Center of Behavioral Brain Sciences, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Behav Brain Res. 2014 May 15;265:49-52. doi: 10.1016/j.bbr.2014.02.011. Epub 2014 Feb 15.
The amygdala is a crucial brain site for acquisition and expression of conditioned fear. Neuropeptides such as somatostatin play a critical role in regulating the activity of the amygdala. In the present study, the specific somatostatin receptor type 2 (SSTR2) agonist L-054,264 was injected into the amygdala of rats either before fear acquisition or before the expression test on conditioned fear measured by fear-potentiated startle. L-054,264 injections strongly attenuated fear expression but did not affect fear acquisition. This suggests that amygdaloid SSTR2 plays an important role in the modulation of fear memory expression.
杏仁核是获得和表达条件性恐惧的关键脑区。神经肽，如生长抑素，在调节杏仁核的活动中起着关键作用。在本研究中，特定的生长抑素受体 2 型（SSTR2）激动剂 L-054,264 在恐惧获得之前或通过恐惧增强的 startle 测量的条件性恐惧表达测试之前注射到大鼠的杏仁核中。L-054,264 注射强烈减弱了恐惧表达，但不影响恐惧获得。这表明杏仁核 SSTR2 在恐惧记忆表达的调制中起着重要作用。
