BIOALVO, S.A., Tec Labs Centro de Inovação, Campus da FCUL, Campo Grande, Lisboa 1749-016, Portugal.
Centro de Química e Bioquímica (CQB) and Departamento de Química e Bioquímica (DQB), Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa 1749-016, Portugal.
Mar Drugs. 2014 Feb 17;12(2):1066-101. doi: 10.3390/md12021066.
The marine environment harbors a number of macro and micro organisms that have developed unique metabolic abilities to ensure their survival in diverse and hostile habitats, resulting in the biosynthesis of an array of secondary metabolites with specific activities. Several of these metabolites are high-value commercial products for the pharmaceutical and cosmeceutical industries. The aim of this review is to outline the paths of marine natural products discovery and development, with a special focus on the compounds that successfully reached the market and particularly looking at the approaches tackled by the pharmaceutical and cosmetic companies that succeeded in marketing those products. The main challenges faced during marine bioactives discovery and development programs were analyzed and grouped in three categories: biodiversity (accessibility to marine resources and efficient screening), supply and technical (sustainable production of the bioactives and knowledge of the mechanism of action) and market (processes, costs, partnerships and marketing). Tips to surpass these challenges are given in order to improve the market entry success rates of highly promising marine bioactives in the current pipelines, highlighting what can be learned from the successful and unsuccessful stories that can be applied to novel and/or ongoing marine natural products discovery and development programs.
海洋环境中蕴藏着许多微生物和宏观生物，它们发展出了独特的代谢能力，以确保在多样化和恶劣的生境中生存，从而合成了一系列具有特定活性的次生代谢产物。其中一些代谢产物是制药和化妆品行业的高价值商业产品。本文的目的是概述海洋天然产物的发现和开发途径，特别关注那些成功进入市场的化合物，并特别研究了制药和化妆品公司在成功营销这些产品时所采用的方法。分析并将海洋生物活性物质发现和开发计划中面临的主要挑战分为三类：生物多样性（海洋资源的可及性和高效筛选）、供应和技术（生物活性物质的可持续生产和作用机制的知识）以及市场（工艺、成本、合作和营销）。为了提高当前管线中极有前途的海洋生物活性物质进入市场的成功率，本文提供了克服这些挑战的建议，重点介绍了从成功和失败的案例中可以吸取的经验教训，并将其应用于新的和/或正在进行的海洋天然产物发现和开发计划。
