伊朗和西方国家乳腺癌及其不同组织病理学亚型的年龄特异性发病率变化。
Age - specific incidence rate change at breast Cancer and its different histopathologic subtypes in Iran and Western countries.
机构信息
Maryam Sadat Hosseini, Maliheh Arab, Professor of Gyneco-Oncology, Preventative Gynecology Research Center (PGRC), Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Behzad Nemati Honar, Assistant Professor of General Surgery. Preventative Gynecology Research Center (PGRC), Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Pak J Med Sci. 2013 Nov;29(6):1354-7.
OBJECTIVE
The aim of the present study was to determine the frequency and age-specific incidence rate of different histopathologic subtypes of breast cancer in Iran, and compare it to neighboring and Western countries and to discuss the probable effective main factors.
METHODS
National data from cancer registry for 6265 female breast cancer patients were studied in 10 histopathologic groups.
RESULTS
The most common tumor was ductal carcinoma (89%). The peak age - specific incidence rate of breast cancer in total, and for epithelial, non-epithelial and ductal carcinomas were all 50-59 years, and it decreased in older age. It is in contrast to US SEER report which shows the incidence increases in higher age.
CONCLUSION
Three main factors including younger age of Iranian patients, probable more ERN tumors and different histopathological profile of breast cancer in Iran might be considered and studied to explain different slope of breast cancer after menopause compared to other countries.
目的
本研究旨在确定伊朗不同组织病理学亚型乳腺癌的频率和年龄特异性发病率，并将其与邻国和西方国家进行比较，并讨论可能的主要影响因素。
方法
对 10 个组织病理学组的 6265 名女性乳腺癌患者的国家癌症登记数据进行了研究。
结果
最常见的肿瘤是导管癌（89%）。乳腺癌的总年龄特异性发病率峰值，以及上皮性、非上皮性和导管性癌的发病率峰值均为 50-59 岁，之后随年龄增长而下降。这与美国 SEER 报告显示的发病率随年龄增长而增加的情况形成对比。
结论
伊朗患者年龄较小、可能存在更多 ERN 肿瘤以及伊朗乳腺癌的组织病理学特征不同这三个主要因素可能需要进一步研究，以解释与其他国家相比伊朗绝经后乳腺癌发病率曲线的不同。
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