Association between CC10 +38A/G polymorphism and asthma risk: A meta-analysis.

OBJECTIVES

A number of studies conducted to assess the association between Clara cell 10-kDa protein (CC10) +38A/G polymorphism and susceptibility to asthma have yielded inconsistent and inconclusive results. In the present study, the possible association was assessed by a meta-analysis.

METHODS

Relevant articles were identified for the period ranging from Jan 1998 up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed effects or random-effects models.

RESULTS

Ten case-control studies with a total of 1529 asthma cases and 2399 controls were included in this meta-analysis. The association between CC10 +38A/G polymorphism and asthma risk was determined in dominant model, recessive model, additive model, and codominant model. In dominant model, CC10 +38A/G polymorphism seemed to be associated with elevated asthma risk (OR = 1.62; 95% CI, 1.23-2.12; P = 0.0005). Subgroup analyses by ethnicity also found significant associations between this polymorphism and asthma risk in Asians and Caucasians. RESULTS from other genetic models further identified this possible association.

CONCLUSION

This meta-analysis suggests that CC10 +38A/G polymorphism confers asthma risk.