Zhao Guangri, Lin Xiaodan, Zhou Ming, Zhao Jian
Guangri Zhao, Department of Chest Surgery, Department of Chest Surgery, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, China.
Xiaodan Lin, Department of Radiotherapy, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, China.
Pak J Med Sci. 2013 Nov;29(6):1439-43. doi: 10.12669/pjms.296.3724.
A number of studies conducted to assess the association between Clara cell 10-kDa protein (CC10) +38A/G polymorphism and susceptibility to asthma have yielded inconsistent and inconclusive results. In the present study, the possible association was assessed by a meta-analysis.
Relevant articles were identified for the period ranging from Jan 1998 up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed effects or random-effects models.
Ten case-control studies with a total of 1529 asthma cases and 2399 controls were included in this meta-analysis. The association between CC10 +38A/G polymorphism and asthma risk was determined in dominant model, recessive model, additive model, and codominant model. In dominant model, CC10 +38A/G polymorphism seemed to be associated with elevated asthma risk (OR = 1.62; 95% CI, 1.23-2.12; P = 0.0005). Subgroup analyses by ethnicity also found significant associations between this polymorphism and asthma risk in Asians and Caucasians. RESULTS from other genetic models further identified this possible association.
This meta-analysis suggests that CC10 +38A/G polymorphism confers asthma risk.
多项旨在评估克拉拉细胞10 kDa蛋白（CC10）+38A/G多态性与哮喘易感性之间关联的研究得出了不一致且不确定的结果。在本研究中，通过荟萃分析评估了可能的关联。
确定了1998年1月至2013年3月期间的相关文章。汇总比值比（OR）及其95%置信区间（CI）通过固定效应或随机效应模型适当得出。
本荟萃分析纳入了10项病例对照研究，共1529例哮喘病例和2399例对照。在显性模型、隐性模型、加性模型和共显性模型中确定了CC10 +38A/G多态性与哮喘风险之间的关联。在显性模型中，CC10 +38A/G多态性似乎与哮喘风险升高相关（OR = 1.62；95% CI，1.23 - 2.12；P = 0.0005）。按种族进行的亚组分析也发现该多态性与亚洲人和高加索人中的哮喘风险之间存在显著关联。其他遗传模型的结果进一步证实了这种可能的关联。
本荟萃分析表明CC10 +38A/G多态性会增加哮喘风险。
