Kirch W, Logemann C, Heidemann H, Santos S R, Ohnhaus E E
I. Medizinische Klinik, Christian Albrechts University of Kiel, F.R.G.
J Cardiovasc Pharmacol. 1987;10 Suppl 10:S74-5.
The effect of nitrendipine in two different dosages on digoxin plasma levels, urinary recovery, and systolic time intervals was investigated in eight healthy volunteers. Following an adequate loading dose of the glycoside, 0.25 mg digoxin twice daily was given alone for 2 weeks orally. After that, 0.25 mg digoxin twice daily was administered for two 1-week periods combined with nitrendipine, 10 mg or 20 mg once daily. The study was completed with a second digoxin monotherapy phase lasting seven days. Nitrendipine, 20 mg daily, led to a significant increase of the digoxin plasma concentration and of its area under the plasma concentration-time curve (AUC0-12) compared with digoxin monotherapy. Thus, AUC0-12 was 9.7 +/- 0.75 ng ml-1 h (X +/- SEM) when digoxin was given alone and was 11.2 +/- 0.92 ng ml-1 h under coadministration of the calcium antagonist (p less than 0.05). Nitrendipine in the dosage of 10 mg once daily caused a small, insignificant tendency to elevate digoxin plasma levels. In conclusion, nitrendipine, 20 mg daily, causes a significant increase of digoxin plasma concentration and of its AUC, which in certain patients might be of clinical relevance.
在八名健康志愿者中研究了两种不同剂量的尼群地平对地高辛血药浓度、尿回收率和收缩时间间期的影响。在给予足够负荷剂量的糖苷后，每天口服0.25mg地高辛，每日两次，单独服用2周。之后，每天口服0.25mg地高辛，每日两次，与尼群地平联合服用两个1周疗程，尼群地平剂量为每日10mg或20mg。研究以持续7天的第二个地高辛单一疗法阶段完成。与地高辛单一疗法相比，每日20mg的尼群地平导致地高辛血药浓度及其血药浓度-时间曲线下面积（AUC0-12）显著增加。因此，单独给予地高辛时，AUC0-12为9.7±0.75ng ml-1 h（X±SEM），在联合使用钙拮抗剂时为11.2±0.92ng ml-1 h（p<0.05）。每日一次10mg剂量的尼群地平使地高辛血药浓度有轻微的、不显著的升高趋势。总之，每日20mg的尼群地平可使地高辛血药浓度及其AUC显著增加，这在某些患者中可能具有临床意义。
