Hutt H J, Kirch W, Dylewicz P, Ohnhaus E E
Arch Toxicol Suppl. 1986;9:209-12. doi: 10.1007/978-3-642-71248-7_27.
The dose-dependence of the nifedipine/digoxin interaction was investigated in seven healthy volunteers. After an adequate loading dose of digoxin for two weeks, 0.25 mg digoxin was given alone orally twice daily. Afterwards, 0.25 mg digoxin was administered twice daily for three one week periods combined with capsules of nifedipine 5 mg, 10 mg or 20 mg (ADA-LAT) respectively on a three times daily basis. Subsequently the study was completed with a digoxin monotherapy phase lasting seven days. All three doses of nifedipine administered led to a significant increase of the digoxin plasma concentrations and of the area under the plasma concentration-time curve (AUC) compared with digoxin monotherapy. In conclusion, nifedipine causes a slight but significant increase of digoxin plasma concentrations and of its AUC (15%). This effect was not dependent on the nifedipine dose administered.
在七名健康志愿者中研究了硝苯地平/地高辛相互作用的剂量依赖性。在给予足够的地高辛负荷剂量两周后，单独口服0.25mg地高辛，每日两次。之后，在三个为期一周的时间段内，每日两次给予0.25mg地高辛，同时分别每日三次联合服用5mg、10mg或20mg硝苯地平胶囊（ADA-LAT）。随后，研究进入为期七天的地高辛单一疗法阶段而结束。与地高辛单一疗法相比，所有三种剂量的硝苯地平给药均导致地高辛血浆浓度及血浆浓度-时间曲线下面积（AUC）显著增加。总之，硝苯地平可使地高辛血浆浓度及其AUC轻微但显著增加（15%）。这种效应不依赖于所给予的硝苯地平剂量。
