Block C H, Barnes K L, Ferrario C M
Department of Brain and Vascular Research, Cleveland Clinic Foundation, Ohio 44106.
J Cardiovasc Pharmacol. 1987;10 Suppl 12:S230-4.
To define the neurochemical substrates underlying cardiovascular regulatory mechanisms in the canine dorsal medulla, we characterized immunocytochemically the organization of substance P (SP) in the dorsomedial medulla. Substance P immunoreactivity was the most dense in the dorsal nucleus tractus solitarii (nTS). Varicose fibers and cells containing this neuropeptide were localized in the dorsal motor nucleus of the vagus (dmnX) and nucleus commissuralis. A few scattered fibers were observed within the area postrema. The distribution of this peptide suggests a topographical organization within the dorsomedial medulla of the dog that is closely related to the cytoarchitectural organization. In addition, the patterns of SP immunoreactivity overlap the distribution of vagal afferent fibers. These observations are discussed in relation to the possible function of SP in the dorsomedial medulla.
为了确定犬延髓背侧心血管调节机制的神经化学底物，我们通过免疫细胞化学方法对延髓背内侧的P物质（SP）组织进行了表征。P物质免疫反应性在孤束核（nTS）中最为密集。含有这种神经肽的曲张纤维和细胞位于迷走神经背运动核（dmnX）和连合核中。在最后区观察到一些散在的纤维。这种肽的分布表明犬延髓背内侧存在一种与细胞构筑组织密切相关的拓扑组织。此外，SP免疫反应性模式与迷走神经传入纤维的分布重叠。本文结合SP在延髓背内侧可能的功能对这些观察结果进行了讨论。
