Diz D I, Block C H, Barnes K L, Ferrario C M
J Hypertens Suppl. 1986 Dec;4(6):S468-71.
Specific angiotensin II (ANG II) binding sites in the dorsal aspects of the medulla oblongata of dogs and rats were shown previously to be dependent upon intact sensory and motor components of the vagus nerve. The present studies compared the distribution of ANG II binding sites in the canine medulla with the visualization of substance P immunoreactive fibres, since this peptide is known to be present in vagal afferent fibres. Dense bands of substance P-containing fibres were found to cap the tractus solitarius (TS) in the dorsal subdivision of the nucleus tractus solitarii (nTS) at a level corresponding to the region of highest ANG II binding. In addition, moderate densities of both substance P immunoreactivity and ANG II binding sites were dually localized in the medial nTS and the ventral portion of the dorsal motor nucleus of the vagus (dmnX). Since previous studies indicated that ANG II binding sites are associated with vagal afferent fibres in the nTS and efferent motor neurons in the dmnX, their apparent association with substance P immunoreactive fibres suggests that a functional interaction may occur between these two peptides in the central integration of cardiovascular function.
先前研究表明，犬类和大鼠延髓背侧存在特异性血管紧张素II（ANG II）结合位点，其依赖于完整的迷走神经感觉和运动成分。本研究将犬类延髓中ANG II结合位点的分布与P物质免疫反应性纤维的可视化进行了比较，因为已知该肽存在于迷走神经传入纤维中。发现在孤束核（nTS）背侧亚区的孤束（TS）顶部，有密集的含P物质纤维带，其位置对应于ANG II结合最高的区域。此外，P物质免疫反应性和ANG II结合位点的中等密度在nTS内侧和迷走神经背运动核（dmnX）腹侧部分双重定位。由于先前的研究表明，ANG II结合位点与nTS中的迷走神经传入纤维和dmnX中的传出运动神经元相关，它们与P物质免疫反应性纤维的明显关联表明，在心血管功能的中枢整合中，这两种肽之间可能发生功能相互作用。
