薄层色谱法中选定药物的检测进展
Detection progress of selected drugs in TLC.
作者信息
Pyka Alina
机构信息
Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Silesia, 4 Jagiellońska Street, 41-200 Sosnowiec, Poland.
出版信息
Biomed Res Int. 2014;2014:732078. doi: 10.1155/2014/732078. Epub 2014 Jan 16.
This entry describes applications of known indicators and dyes as new visualizing reagents and various visualizing systems as well as photocatalytic reactions and bioautography method for the detection of bioactive compounds including drugs and compounds isolated from herbal extracts. Broadening index, detection index, characteristics of densitometric band, modified contrast index, limit of detection, densitometric visualizing index, and linearity range of detected compounds were used for the evaluation of visualizing effects of applied visualizing reagents. It was shown that visualizing effect depends on the chemical structure of the visualizing reagent, the structure of the substance detected, and the chromatographic adsorbent applied. The usefulness of densitometry to direct detection of some drugs was also shown. Quoted papers indicate the detection progress of selected drugs investigated by thin-layer chromatography (TLC).
本条目描述了已知指示剂和染料作为新型可视化试剂的应用、各种可视化系统以及用于检测生物活性化合物（包括药物和从草药提取物中分离出的化合物）的光催化反应和生物自显影方法。使用展宽指数、检测指数、光密度谱带特征、修正对比度指数、检测限、光密度可视化指数以及检测化合物的线性范围来评估所应用可视化试剂的可视化效果。结果表明，可视化效果取决于可视化试剂的化学结构、被检测物质的结构以及所应用的色谱吸附剂。还展示了光密度法直接检测某些药物的实用性。引用的论文表明了通过薄层色谱法（TLC）对所选药物的检测进展。
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