Chen Cheng, Wang Lingyan, Liao Qi, Xu Leiting, Huang Yi, Zhang Cheng, Ye Huadan, Xu Xuting, Ye Meng, Duan Shiwei
1 Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University , Ningbo, China .
Genet Test Mol Biomarkers. 2014 Mar;18(3):187-95. doi: 10.1089/gtmb.2013.0425. Epub 2014 Feb 19.
The aim of this study was to determine whether six genetic polymorphisms confer susceptibility to colorectal cancer (CRC).
A systematic search for candidate genes of CRC was performed among several online databases, including PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang online libraries. After a comprehensive filtering procedure, we harvested five genes, including MGMT (rs12917 and rs2308321), ADH1B (rs1229984), SOD2 (rs4880), XPC (rs2228001), and PPARG (rs1801282). Using the REVMAN and Stata software, six meta-analyses were conducted for associations between CRC and the just-mentioned genetic variants.
A total of 34 comparative studies among 17,289 cases and 54,927 controls were involved in our meta-analyses. Significant association was found between ADH1B rs1229984 polymorphism and CRC (p=0.03, odds ratio [OR]=1.18, 95% confidence interval [CI]=1.01-1.36). We also found significant association between PPARG rs1801282 polymorphism and CRC (p=0.004, OR=1.498, 95% CI=1.139-1.970), and this significant association is specific in Caucasians (p=0.004, OR=1.603, 95% CI=1.165-2.205).
The current meta-analysis has established that ADH1B (rs1229984) and PPARG (rs1801282) are two risk variants of CRC.
本研究旨在确定六种基因多态性是否会使人易患结直肠癌（CRC）。
在多个在线数据库中对CRC候选基因进行系统检索，这些数据库包括PubMed、Embase、Web of Science、Cochrane图书馆、中国知网和万方在线图书馆。经过全面筛选程序，我们获取了五个基因，包括MGMT（rs12917和rs2308321）、ADH1B（rs1229984）、SOD2（rs4880）、XPC（rs2228001）和PPARG（rs1801282）。使用REVMAN和Stata软件，对CRC与上述基因变异之间的关联进行了六项荟萃分析。
我们的荟萃分析共纳入了17289例病例和54927例对照的34项比较研究。发现ADH1B rs1229984多态性与CRC之间存在显著关联（p = 0.03，比值比[OR] = 1.18，95%置信区间[CI] = 1.01 - 1.36）。我们还发现PPARG rs1801282多态性与CRC之间存在显著关联（p = 0.004，OR = 1.498，95% CI = 1.139 - 1.970），并且这种显著关联在白种人中具有特异性（p = 0.004，OR = 1.603，95% CI = 1.165 - 2.205）。
当前的荟萃分析确定ADH1B（rs1229984）和PPARG（rs1801282）是CRC的两个风险变异。
