Davenas E, Beauvais F, Amara J, Oberbaum M, Robinzon B, Miadonna A, Tedeschi A, Pomeranz B, Fortner P, Belon P
INSERM U 200, Université Paris-Sud, Clamart, France.
Nature. 1988 Jun 30;333(6176):816-8. doi: 10.1038/333816a0.
When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. The latter can be demonstrated at dilutions of anti-IgE that range from 1 x 10(2) to 1 x 10(120); over that range, there are successive peaks of degranulation from 40 to 60% of the basophils, despite the calculated absence of any anti-IgE molecules at the highest dilutions. Since dilutions need to be accompanied by vigorous shaking for the effects to be observed, transmission of the biological information could be related to the molecular organization of water.
当人类多形核嗜碱性粒细胞（一种表面带有免疫球蛋白E（IgE）型抗体的白细胞）暴露于抗IgE抗体时，它们会从细胞内颗粒中释放组胺，并改变其染色特性。后者在抗IgE稀释度为1×10²至1×10¹²⁰时均可得到证实；在该稀释范围内，尽管在最高稀释度下计算得出不存在任何抗IgE分子，但仍有40%至60%的嗜碱性粒细胞相继出现脱颗粒峰值。由于为观察到这些效应，稀释过程需要剧烈振荡，因此生物信息的传递可能与水的分子结构有关。
