用于检测单胺氧化酶活性和细胞成像的荧光探针。
Fluorescent probes for detecting monoamine oxidase activity and cell imaging.
作者信息
Li Xuefeng, Zhang Huatang, Xie Yusheng, Hu Yi, Sun Hongyan, Zhu Qing
机构信息
Institute of Bioengineering, Zhejiang University of Technology, Chaowang Road 18, Hangzhou 310014, China.
出版信息
Org Biomol Chem. 2014 Apr 7;12(13):2033-6. doi: 10.1039/c3ob42326c. Epub 2014 Feb 20.
A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL(-1) respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells.
基于氧化和β-消除机制，报道了一系列用于单胺氧化酶（MAOs）的新型荧光探针。MAO-A和MAO-B探针的检测限分别确定为3.5和6.0 μg mL(-1)。这些探针对MAOs表现出很强的活性，尤其是对MAO-B。还成功地对MCF-7细胞进行了细胞成像研究。
Zotero 插件