用于活细胞中单胺氧化酶的基于活性的荧光报告分子。
Activity-based fluorescent reporters for monoamine oxidases in living cells.
作者信息
Albers Aaron E, Rawls Katherine A, Chang Christopher J
机构信息
Department of Chemistry, University of California, Berkeley, CA 94720, USA.
出版信息
Chem Commun (Camb). 2007 Nov 28(44):4647-9. doi: 10.1039/b713190a. Epub 2007 Oct 9.
DOI:10.1039/b713190a
PMID:17989820
Abstract
Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/beta-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagents.
摘要
单胺氧化酶报告分子1和2（MR1和MR2）是底物连接活性探针，其利用串联胺氧化/β-消除机制直接且特异性地在体外和活细胞中检测单胺氧化酶的化学反应，无需额外的酶或其他活化试剂。
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