基于抑制剂结构的单胺氧化酶 A（MAO-A）近红外荧光探针的设计与合成及其在活细胞和体内的应用。
Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo.
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.
出版信息
Chem Commun (Camb). 2019 Feb 21;55(17):2477-2480. doi: 10.1039/c8cc10084e.
PMID:30734773
Abstract
A series of near-infrared fluorescent probes based on inhibitor (clorgyline) structure-guided design were synthesized for the specific detection of MAO-A in cells and in vivo. Moreover, we have successfully used the high specificity of one of the probes to visualize MAO-A activity in zebrafish and tumor tissue for the first time.
摘要
基于抑制剂（氯丙嗪）结构导向设计的一系列近红外荧光探针被合成，用于细胞内和体内 MAO-A 的特异性检测。此外，我们还成功地利用其中一个探针的高特异性，首次在斑马鱼和肿瘤组织中可视化 MAO-A 活性。
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