van der Putte S C, Toonstra J, van Wichen D F, van Unnik J A, van Vloten W A
Institute of Pathology, University of Utrecht, The Netherlands.
Acta Derm Venereol. 1988;68(3):202-8.
Reactivity for Ki-1 antibody was studied in 145 patients with a large variety of cutaneous disorders. The antigen was consistently expressed and by a high proportion of tumour cells in infiltrates in which atypical cells revealed a 'histiocytic' appearance, i.e. lymphomatoid papulosis (LP), T-immunoblastic lymphoma with the characteristic of true histiocytic lymphoma, Hodgkin's disease, T-blast cell proliferation with giant multivesicular bodies, concurrent LP and mycosis fungoides (MF), and two cases of MF. Ki-1+ cells with the usual morphology of atypical T-cells formed a major component in 2 other cases of MF, and a minor component in 7 other cases of MF. A possible non-neoplastic counterpart was found in small to medium-sized Ki-1+ cells, including blast cells, which occurred occasionally in the T-cell infiltrates of eczema, actinic reticuloid, lichen planus and pityriasis lichenoides. Small Ki-1+ cells which were observed in the reactive B/T cell component of lymphocytoma cutis but also in similar components occurring occasionally in non-epidermotropic cutaneous T-cell lymphoma, and malignant B-cell lymphomas, might be analogous to the Ki-1+ cells in normal lymphoid tissue.
对145例患有多种皮肤疾病的患者进行了Ki-1抗体反应性研究。在浸润中，当非典型细胞呈现“组织细胞样”外观时，即淋巴瘤样丘疹病（LP）、具有真性组织细胞淋巴瘤特征的T免疫母细胞淋巴瘤、霍奇金病、具有巨大多囊泡体的T原始细胞增殖、LP与蕈样肉芽肿（MF）并发以及2例MF时，抗原持续表达且高比例的肿瘤细胞表达该抗原。在另外2例MF中，具有非典型T细胞常见形态的Ki-1+细胞构成主要成分，在另外7例MF中构成次要成分。在小到中等大小的Ki-1+细胞中发现了一种可能的非肿瘤对应物，包括原始细胞，这些细胞偶尔出现在湿疹、光化性类网状细胞增生症、扁平苔藓和苔藓样糠疹的T细胞浸润中。在皮肤淋巴细胞瘤的反应性B/T细胞成分中观察到的小Ki-1+细胞，也在非亲表皮性皮肤T细胞淋巴瘤和恶性B细胞淋巴瘤中偶尔出现的类似成分中观察到，可能类似于正常淋巴组织中的Ki-1+细胞。
