Baker B S, Lambert S, Powles A V, Valdimarsson H, Fry L
Department of Immunology, St. Mary's Hospital Medical School, London England.
Acta Derm Venereol. 1988;68(3):209-17.
T lymphocyte and dendritic cell subpopulations were counted in three biopsies each of endogenous eczema and pityriasis rosea and two of lichen planus and compared with previous findings in psoriatic lesions. In common with psoriasis, proportionately more CD4 T cells than CD8 T cells were DR+ in both epidermis and dermis of all lesions. In addition, total numbers of epidermal dendritic cells were significantly increased in endogenous eczema and pityriasis rosea, and variably in lichen planus lesions. Interestingly, a DR+T6- subpopulation of dendritic cells was present in varying proportions in all three skin lesion types. Electron microscopy of DR+T6- dendritic cells from psoriatic lesions, using an immunogold staining technique, showed the cells to be of the Langerhans' cell lineage. DR+T6- dendritic cells are a subpopulation of Langerhans' cells which are not specific to psoriasis, but present in the lesions of other benign, inflammatory skin conditions in which CD4 T cells are preferentially activated.
对3例内源性湿疹、3例玫瑰糠疹以及2例扁平苔藓的活检样本中的T淋巴细胞和树突状细胞亚群进行计数，并与先前银屑病皮损的研究结果进行比较。与银屑病一样，在所有皮损的表皮和真皮中，DR⁺的CD4 T细胞比CD8 T细胞比例更高。此外，内源性湿疹和玫瑰糠疹中表皮树突状细胞总数显著增加，扁平苔藓皮损中则有不同程度增加。有趣的是，在所有三种皮肤病变类型中，均存在不同比例的DR⁺T6⁻树突状细胞亚群。运用免疫金染色技术对银屑病皮损中的DR⁺T6⁻树突状细胞进行电子显微镜观察，结果显示这些细胞属于朗格汉斯细胞系。DR⁺T6⁻树突状细胞是朗格汉斯细胞的一个亚群，并非银屑病所特有，而是存在于其他良性炎症性皮肤病损中，这些病损中CD4 T细胞优先被激活。
