Bos J D, Huisman P M, Krieg S R, Faber W R
Acta Derm Venereol. 1985;65(2):132-7.
Pityriasis rosea is a skin disease which is obscure in its etiology and pathogenesis. We studied its immunopathology by immunophenotyping the inflammatory cells in situ using monoclonal antibodies that define leukocyte subsets. Findings as to T-cells and their major subsets did not reveal disease-specific data. Monocytes stained only rarely. Neither natural killer cells, B-cells nor plasma cells were ever found. An unexpected finding was the presence within the infiltrates and rarely within the epidermis of cells having the immunophenotype of interdigitating cells (RFD1+). Intense and dendritic staining with anti-T6 and anti-HLA-DR indicated Langerhans cells to be present in the dermal infiltrates, in between these infiltrates in the papillary dermis, and focally within the parakeratotic horny layer. This Langerhans' cell pattern provides evidence for dermal Langerhans cell compartmentalization and transepidermal Langerhans' cell elimination. Such a distribution indicates a change in Langerhans' cell migration processes in pityriasis rosea pathogenesis.
玫瑰糠疹是一种病因和发病机制尚不明确的皮肤病。我们通过使用定义白细胞亚群的单克隆抗体对炎症细胞进行原位免疫表型分析，研究了其免疫病理学。关于T细胞及其主要亚群的研究结果并未揭示出疾病特异性数据。单核细胞很少被染色。从未发现自然杀伤细胞、B细胞或浆细胞。一个意外的发现是，在浸润物中以及很少在表皮内存在具有指状突细胞免疫表型（RFD1+）的细胞。用抗T6和抗HLA-DR进行的强烈树突状染色表明，朗格汉斯细胞存在于真皮浸润物中、乳头真皮中这些浸润物之间以及灶性存在于角化不全的角质层内。这种朗格汉斯细胞模式为真皮朗格汉斯细胞的分隔和经表皮朗格汉斯细胞的清除提供了证据。这种分布表明玫瑰糠疹发病机制中朗格汉斯细胞迁移过程发生了变化。
