Aoshima T, Oguchi M
Division of Dermatology, Otsu Red Cross Hospital, Japan.
Acta Derm Venereol. 1988;68(3):261-4.
A case of granulomatous contact dermatitis due to gold earrings for pierced ears was studied ultrastructurally. The patient was a 24-year-old woman, who had reddish brown papules on the earlobes. Patch test using gold sodium thiomalate proved strong positive, with blister formation. Histological observation of the papule showed dense cell infiltration throughout the full thickness of the dermis. Ultrastructurally, dermal infiltrating cells consisted of lymphocytes and histiocytes. Unusual crystalline inclusion bodies were observed in the cytoplasm of these cells. These structures were elliptical, not encapsulated and showed a regular fingerprint-like pattern of parallel lines along the short axis. The width of the lines and their intervals was 12 nm. These findings suggest that continuous contact between gold and dermis may induce inflammation, causing granulomatous changes and the development of crystalline inclusion bodies.
对一例因穿耳洞佩戴金耳环引起的肉芽肿性接触性皮炎进行了超微结构研究。患者为一名24岁女性，其耳垂上有红棕色丘疹。使用硫代苹果酸金钠进行斑贴试验显示强阳性，并形成水疱。丘疹的组织学观察显示真皮全层有密集的细胞浸润。超微结构上，真皮浸润细胞由淋巴细胞和组织细胞组成。在这些细胞的细胞质中观察到异常的结晶包涵体。这些结构呈椭圆形，无包膜，沿短轴显示出规则的指纹状平行线图案。线的宽度及其间距为12纳米。这些发现表明金与真皮的持续接触可能诱发炎症，导致肉芽肿性改变和结晶包涵体的形成。
