Iwatsuki K, Tagami H, Moriguchi T, Yamada M
Arch Dermatol. 1982 Aug;118(8):608-11.
An allergic sensitivity to gold earrings produced a lymphadenoid reaction with germinal centers in the dermis of the pierced earlobes of a 21-year-old woman, However, a patch test for 1% gold sodium thiomalate gave a long-lasting, clinically and histologically eczematous response. Electron microscopic and cytochemical observations showed that non-T lymphocytes and plasma cells were dominant in the dermal infiltrate of the lesions, whereas lymphocytes with convoluted nuclei (which were probably T cells) and monocytes invaded the epidermis in the patch test site. These findings suggest that continuous exposure of the dermis to gold in a sensitized person may induce a lymphadenoid cellular reaction different from the histologic findings seen after contact with the epidermis.
一名21岁女性对金耳环产生过敏反应，在其穿耳洞的耳垂真皮层引发了伴有生发中心的淋巴腺样反应。然而，对1%硫代苹果酸钠金进行的斑贴试验产生了持久的、临床和组织学上的湿疹样反应。电子显微镜和细胞化学观察表明，病变真皮浸润中以非T淋巴细胞和浆细胞为主，而在斑贴试验部位，核呈卷曲状的淋巴细胞（可能是T细胞）和单核细胞侵入了表皮。这些发现提示，致敏个体的真皮持续接触金可能会诱发一种与接触表皮后所见组织学表现不同的淋巴腺样细胞反应。
