远古微生物的 RIO 激酶。
The ancient microbial RIO kinases.
机构信息
From the Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 and the University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201.
出版信息
J Biol Chem. 2014 Apr 4;289(14):9488-92. doi: 10.1074/jbc.R113.538090. Epub 2014 Feb 19.
Abstract
The RIO kinases existed before the split between Archaea and Eubacteria and are essential in eukaryotes. Although much has been elucidated in the past few years regarding the function of these proteins in eukaryotes, questions remain about their role in prokaryotes. Comparison of structure and sequence suggests that the ancient RIO kinases may have similar functional properties in prokaryotes as they do in eukaryotes. The conservation of charge distribution, functional residues, and overall structure supports a role for these proteins in ribosome interactions, as is their purpose in eukaryotes. However, a lack of study in this area has left little direct evidence in support of this function.
摘要
RIO 激酶存在于古菌和真细菌分裂之前，对真核生物至关重要。尽管在过去几年中，人们已经阐明了这些蛋白质在真核生物中的功能，但关于它们在原核生物中的作用仍存在疑问。结构和序列的比较表明，古老的 RIO 激酶在原核生物中的功能特性可能与在真核生物中相似。电荷分布、功能残基和整体结构的保守性支持这些蛋白质在核糖体相互作用中的作用，就像它们在真核生物中的作用一样。然而，该领域缺乏研究，几乎没有直接证据支持这一功能。
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