Vaughan Sue, Wallis Marianne, Polit Denise, Steele Mike, Shum David, Morris Norman
Griffith University, School of Rehabilitation Sciences, G02 Gold Coast Campus, Gold Coast, QLD 4222, Australia.
University of the Sunshine Coast, School of Nursing and Midwifery, Sunshine Coast, QLD, Australia Griffith University, Research Centre for Health Practice Innovation, Gold Coast, QLD, Australia.
Age Ageing. 2014 Sep;43(5):623-9. doi: 10.1093/ageing/afu010. Epub 2014 Feb 18.
to test the effect of a 16-week multimodal exercise program on neurocognitive and physical functioning and brain-derived neurotrophic factor (BDNF).
a single-blinded, parallel-group randomised controlled trial.
university campus and community-based halls.
forty-nine women aged 65 to 75 years, with no cognitive impairment and not undertaking more than 1 h of formal exercise training per week.
the intervention group attended a 60-min multimodal class twice each week which included cardiovascular, strength and motor fitness training. The primary outcome was neurocognitive functioning and secondary outcomes were physical functioning and plasma levels of BDNF.
twenty-five participants were randomised to the intervention group and 24 to the control group. One control participant withdrew before follow-up data collection. The intervention group performed significantly better than the control group at follow-up (when controlled for baseline) in the Trail Making test A and B, the California Older Adult Stroop test (Word, Interference and Total scores), Controlled Oral Word Association test and the Timed Up-and-Go test, Six-Minute Walk test, One-Legged Stance test and plasma BDNF.
this multimodal exercise program resulted in neurocognitive and physical performance improvements and increased levels of plasma BDNF, in older women, when compared with controls. This RCT provides evidence that a multimodal exercise intervention can achieve larger effect sizes than those generally resulting from single modality interventions. Increases in BDNF levels imply neurogenesis may be a component of the mechanism underpinning the cognitive improvements associated with multimodal exercise.
Australian and New Zealand Clinical Trial Registration Number: ANZCTR12612000451808.
测试一项为期16周的多模式运动计划对神经认知和身体功能以及脑源性神经营养因子（BDNF）的影响。
单盲、平行组随机对照试验。
大学校园和社区礼堂。
49名年龄在65至75岁之间的女性，无认知障碍，且每周进行的正式运动训练不超过1小时。
干预组每周参加两次60分钟的多模式课程，包括心血管、力量和运动健身训练。主要结果是神经认知功能，次要结果是身体功能和BDNF的血浆水平。
25名参与者被随机分配到干预组，24名被分配到对照组。一名对照参与者在随访数据收集前退出。在随访时（在控制基线的情况下），干预组在连线测验A和B、加利福尼亚老年人斯特鲁普测验（单词、干扰和总分）、受控口语联想测验、计时起立行走测验、六分钟步行测验、单腿站立测验以及血浆BDNF方面的表现明显优于对照组。
与对照组相比，这项多模式运动计划使老年女性的神经认知和身体表现得到改善，血浆BDNF水平升高。这项随机对照试验提供了证据，表明多模式运动干预比单模式干预通常产生的效果更大。BDNF水平的升高意味着神经发生可能是多模式运动相关认知改善机制的一个组成部分。
澳大利亚和新西兰临床试验注册号：ANZCTR12612000451808。
