Venkatesan Gomathinayagam, Uppoor Ashita, Naik Dilip G
Department of Periodontology, Manipal College of Dental Sciences, Manipal University, Light House Hill Road, Mangalore, Karnataka, India.
J Indian Soc Periodontol. 2013 Nov;17(6):700-5. doi: 10.4103/0972-124X.124467.
A properly functioning adaptive immune system signifies the best features of life. It is diverse beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad of infections and other challenges. Dendritic cells (DCs) are required to explain how this remarkable system is energized and directed. DCs consist of a family of antigen presenting cells, which are bone-marrow-derived cells that patrol all tissues of the body with the possible exceptions of the brain and testes. DCs function to capture bacteria and other pathogens for processing and presentation to T cells in the secondary lymphoid organs. They serve as an essential link between innate and adaptive immune systems and induce both primary and secondary immune responses. As a result of progress worldwide, there is now evidence of a central role for dendritic cells in initiating antigen-specific immunity and tolerance. This review addresses the origins and migration of DCs to target sites, their basic biology and plasticity in playing a key role in periodontal diseases, and finally, selected strategies being pursued to harness its ability to prevent periodontal diseases.
一个功能正常的适应性免疫系统代表了生命的最佳特性。它的多样性无与伦比，始终具有耐受性，并且能够对多种感染和其他挑战做出适当反应。树突状细胞（DCs）对于解释这个卓越的系统是如何被激活和引导的至关重要。DCs由一类抗原呈递细胞组成，这些细胞来源于骨髓，除了大脑和睾丸外，它们在身体的所有组织中巡逻。DCs的功能是捕获细菌和其他病原体，以便在二级淋巴器官中进行处理并呈递给T细胞。它们是先天免疫系统和适应性免疫系统之间的重要联系，并诱导初次和二次免疫反应。由于全球范围内的研究进展，现在有证据表明树突状细胞在启动抗原特异性免疫和耐受性方面发挥着核心作用。这篇综述探讨了DCs的起源和向靶位点的迁移、它们在牙周疾病中发挥关键作用的基本生物学特性和可塑性，最后还介绍了为利用其预防牙周疾病的能力而正在探索的一些选定策略。
