Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnology Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Res Int. 2020 Dec 9;2020:7279509. doi: 10.1155/2020/7279509. eCollection 2020.
Nowadays, dental implants are a prominent therapeutic approach among dentists for replacing missing teeth. Failure in dental implants is a severe challenge recently. The factors which lead to dental implant failure are known. These factors can be categorized into different groups. In this article, we discussed the immunological aspects of implant failure as one of these groups. Cytokines and immune cells have extensive and various functions in peri-implantitis. The equilibrium between pro and anti-inflammatory cytokines and cells, which involve in this orchestra, has a crucial role in implant prognosis. In conclusion, immune cells, especially macrophages and dendritic cells, almost increased in the patients with implant failure. Also, proinflammatory cytokines were proposed as diagnostic factors according to their higher levels in dental implant rejection.
如今，牙医在修复缺失牙齿方面采用的主要治疗方法是种植牙。种植牙的失败是最近面临的一个严峻挑战。导致种植牙失败的因素是已知的。这些因素可以分为不同的组。在本文中，我们讨论了作为其中一组的种植牙失败的免疫学方面。细胞因子和免疫细胞在种植体周围炎中具有广泛而多样的功能。在这个过程中，涉及到的促炎和抗炎细胞因子之间的平衡对种植体的预后起着至关重要的作用。总之，免疫细胞，尤其是巨噬细胞和树突状细胞，在种植体失败的患者中几乎增加。此外，根据它们在种植牙排斥反应中较高的水平，促炎细胞因子被提出作为诊断因素。
