Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea ; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea ; Department of Conservative Dentistry, Dankook University Dental College, Cheonan, Republic of Korea.
J Tissue Eng. 2013 Dec 10;4:2041731413517705. doi: 10.1177/2041731413517705. eCollection 2013.
Alveolar bone regeneration is a significant challenge in dental implantation. Novel biomaterials and tissue-engineered constructs are under extensive development and awaiting in vivo animal tests to find clinical endpoint. Here, we establish a novel in vivo model, modifying gingivoperiosteoplasty in rat for the alveolar bone regeneration. Rat premaxillary bone defects were filled with silk scaffold or remained empty during the implantation period (up to 6 weeks), and harvested samples were analyzed by micro-computed tomography and histopathology. Empty defects showed increased but limited new bone formation with increasing implantation period. In defects implanted with silk sponge, the bone formation was significantly greater than that of empty defect, indicating an effective role of silk scaffold in the defect model. The modified premaxillary defect model in rat is simple to perform, while mimicking the clinical conditions, finding usefulness for the development of biomaterials and tissue-engineered constructs targeting alveolar bone regeneration in dental implantation.
牙槽骨再生是牙种植的重大挑战。新型生物材料和组织工程构建体正在广泛开发中，等待进行体内动物试验以找到临床终点。在这里，我们建立了一种新的体内模型，通过对大鼠的牙龈骨膜成形术进行改良，以实现牙槽骨再生。在植入期间（最长 6 周），将丝质支架填充到大鼠的前上颌骨骨缺损中，或者使骨缺损保持为空。采集样本并通过微计算机断层扫描和组织病理学进行分析。随着植入时间的增加，空的骨缺损显示出增加但有限的新骨形成。在植入丝质海绵的缺损中，骨形成明显大于空的骨缺损，表明丝质支架在该缺损模型中具有有效作用。大鼠改良的前上颌骨缺损模型操作简单，同时模拟了临床情况，对于开发针对牙种植中牙槽骨再生的生物材料和组织工程构建体具有一定的应用价值。
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