Department of Optometry and Vision Sciences, The University of Melbourne, Australia.
Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):1985-93. doi: 10.1167/iovs.13-13758.
We have developed customized maps that relate visual field and optic nerve head (ONH) regions according to individual anatomy. In this study, we aimed to determine feasible map resolution for research use, and to make a principled recommendation of sector size for clinical applications.
Measurement variability in fovea-ONH distance and angle was estimated from 10 repeat OCT scans of 10 healthy people. Errors in estimating axial length from refractive error were determined from published data. Structure-function maps were generated, and customized to varied clinically-plausible anatomical parameters. For each parameter set (n = 210), 200 maps were generated by sampling from measurement/estimation error distributions. Mapped 1° sectors at each visual field location from each parameter set were normalized to difference from their mean. Variation (90% ranges) in normalized mapped sectors represents the precision of individualized maps.
Standard deviations of repeated measures of fovea-ONH distance and angle were 61 μm and 0.97° (coefficients of variation 1.3% and 12.0%, respectively). Neither measure varied systematically with mean (Spearmans's ρ = 0.26, P = 0.47 for distance, ρ = -0.31, P = 0.39 for angle). Variation (90% ranges) in normalized mapped sectors varied across the visual field and ranged from 3° to 18° when axial length was measured accurately, and from 6° to 32° when axial length was estimated from refractive error.
The 90% ranges represent the minimum feasible ONH sector size at each visual field location. For clinical use an easily interpretable scheme of 30° sectors is suggested.
我们已经开发了根据个体解剖结构定制的视野和视神经头（ONH）区域相关的地图。在这项研究中，我们旨在确定研究使用的可行地图分辨率，并为临床应用推荐合理的扇形区大小。
从 10 名健康人的 10 次 OCT 重复扫描中估计了黄斑区-ONH 距离和角度的测量变异性。从已发表的数据中确定了从屈光不正估计眼轴长度的误差。生成了结构-功能图，并针对各种临床合理的解剖参数进行了定制。对于每个参数集（n=210），通过从测量/估计误差分布中采样生成了 200 个地图。从每个参数集的每个视野位置生成了映射的 1°扇形区，并将其归一化为与平均值的差异。归一化映射扇区的变异性（90%范围）代表个体地图的精度。
黄斑区-ONH 距离和角度的重复测量标准差分别为 61μm 和 0.97°（变异系数分别为 1.3%和 12.0%）。两种测量都没有随平均值系统变化（Spearmans's ρ=0.26，P=0.47 用于距离，ρ=-0.31，P=0.39 用于角度）。归一化映射扇区的变异性（90%范围）在整个视野范围内变化，当眼轴长度测量准确时，范围从 3°到 18°，当眼轴长度从屈光不正估计时，范围从 6°到 32°。
90%范围代表每个视野位置的最小可行 ONH 扇形区大小。对于临床应用，建议采用易于解释的 30°扇形区方案。
