Department of Optometry & Vision Sciences, The University of Melbourne, Melbourne, Australia.
Department of Optometry & Vision Sciences, The University of Melbourne, Melbourne, Australia; Department of Computing and Information Systems, The University of Melbourne, Melbourne, Australia; Visual Neuroscience Group, School of Psychology, University of Nottingham, Nottingham, United Kingdom.
Ophthalmology. 2017 Apr;124(4):554-561. doi: 10.1016/j.ophtha.2016.12.016. Epub 2017 Feb 10.
Interindividual variance in optic nerve head (ONH) position, axial length, and location of the temporal raphe suggest that customizing mapping between visual field locations and ONH sectors for individuals may be clinically useful. Herein we quantify the proportion of the population predicted to have structure-function mappings that markedly deviate from "average," and thus would benefit from customized mapping.
Database study and case report.
Population database of 2836 eyes from the Beijing Eye Study and a single case report of an individual with primary open-angle glaucoma.
Using the morphometric fundus data of the Beijing Eye Study for 2836 eyes and applying a recently developed model based on axial length and ONH position relative to the fovea, we determined for each measurement location in the 24-2 Humphrey (Carl Zeiss Meditec, Dublin, CA) visual field the proportion of eyes for which, in the customized approach as compared with the generalized approach, the mapped ONH sector was shifted into a different sector. We determined the proportion of eyes for which the mapped ONH location was shifted by more than 15°, 30°, or 60°.
Mapping correspondence between locations in visual field space to localized sectors on the ONH.
The largest interindividual differences in mapping are in the nasal step region, where the same visual field location can map to either the superior or inferior ONH, depending on other anatomic features. For these visual field locations, approximately 12% of eyes showed a mapping opposite to conventional expectations.
Anatomically customized mapping shifts the map markedly in approximately 12% of the general population in the nasal step region, where visual field locations can map to the opposite pole of the ONH than conventionally considered. Early glaucomatous damage commonly affects this region; hence, individually matching structure to function may prove clinically useful for the diagnosis and monitoring of progression within individuals.
视神经头（ONH）位置、眼轴长度和颞部裂缝位置的个体差异表明，为个体定制视觉场位置与 ONH 扇区之间的映射可能具有临床意义。本文旨在量化预计有结构-功能映射明显偏离“平均”的人群比例，从而使这些人受益于定制映射。
数据库研究和病例报告。
来自北京眼研究的 2836 只眼的人群数据库和一名原发性开角型青光眼患者的单一病例报告。
利用北京眼研究的形态学眼底数据和基于眼轴长度和 ONH 相对于黄斑的位置的新开发模型，我们确定了 24-2 Humphrey（Carl Zeiss Meditec，Dublin，CA）视野中的每个测量位置，在定制方法与通用方法相比，映射的 ONH 扇区被转移到不同的扇区的眼睛比例。我们确定了映射的 ONH 位置偏移超过 15°、30°或 60°的眼睛比例。
将视觉空间中的位置与 ONH 上的局部扇区进行映射对应。
映射差异最大的是鼻侧步区，同一视野位置可以映射到 ONH 的上或下侧，这取决于其他解剖特征。对于这些视野位置，大约 12%的眼睛表现出与传统预期相反的映射。
在鼻侧步区，解剖定制映射会使大约 12%的普通人群的地图发生明显变化，在这个区域，视野位置可以映射到与传统上认为的相反的 ONH 极。早期青光眼损害通常影响这个区域；因此，个体匹配结构与功能可能对个体的诊断和进展监测具有临床意义。
