Conrad K A, Fagan T C, Simons J A
University of Arizona College of Medicine, Tucson.
J Clin Pharmacol. 1988 May;28(5):436-40. doi: 10.1002/j.1552-4604.1988.tb05756.x.
Pancreatitis and asymptomatic elevations of serum amylase have been reported after therapy with thiazide diuretics. In the current study, the effects of hydrochlorothiazide and tripamide treatment on serum and urinary amylase excretion were investigated in 12 hypertensive volunteers. Two patients developed modest elevations of the serum amylase above the normal range after 12 weeks of treatment with hydrochlorothiazide 50 mg daily, but the mean serum amylase did not change. Hydrochlorothiazide did not produce a statistically significant increase in urinary amylase excretion but did reduce the ratio of salivary amylase/creatinine clearance in a two-hour urine collection. Tripamide 10 mg daily had no effect on serum or urinary amylase.
据报道，使用噻嗪类利尿剂治疗后会出现胰腺炎和血清淀粉酶无症状升高的情况。在本研究中，对12名高血压志愿者研究了氢氯噻嗪和曲帕胺治疗对血清和尿淀粉酶排泄的影响。两名患者在每日服用50毫克氢氯噻嗪治疗12周后，血清淀粉酶出现适度升高，高于正常范围，但血清淀粉酶的平均值没有变化。氢氯噻嗪并未使尿淀粉酶排泄量出现统计学上的显著增加，但在两小时尿液收集过程中确实降低了唾液淀粉酶/肌酐清除率的比值。每日服用10毫克曲帕胺对血清或尿淀粉酶没有影响。
