碱性成纤维细胞生长因子及其与正常组织和肿瘤组织中血管生成的关系。
Basic fibroblast growth factor and its relation to angiogenesis in normal and neoplastic tissue.
作者信息
Schweigerer L
机构信息
Universitäts-Kinderklinik und Deutsches Krebsforschungszentrum (Abteilung für Klassische und Molekulare Genetik), Heidelberg.
出版信息
Klin Wochenschr. 1988 Apr 15;66(8):340-5. doi: 10.1007/BF01735791.
Basic fibroblast growth factor is a protein widely distributed in the organism. It can stimulate the proliferation and differentiation of many cells and it is extremely potent in inducing angiogenesis, the formation of new blood vessels. In this article, some of its structural and biological properties are reviewed. In particular, the possible implications of basic fibroblast growth factor in normal and tumor angiogenesis are considered.
碱性成纤维细胞生长因子是一种广泛分布于生物体中的蛋白质。它能刺激多种细胞的增殖和分化，在诱导血管生成（即新血管的形成）方面具有极强的作用。本文综述了其一些结构和生物学特性。特别探讨了碱性成纤维细胞生长因子在正常血管生成和肿瘤血管生成中的可能影响。
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