Slavin J
Department of Surgery, Aintree Hospitals, Liverpool.
Cell Biol Int. 1995 May;19(5):431-44. doi: 10.1006/cbir.1995.1087.
Acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) are ubiquitous cytokines found in many tissues. They have effects on multiple cell types derived from mesoderm and neuroectoderm, including endothelial cells. In this review the structure and function of the fibroblast growth factor family and its receptors are described. The evidence implicating both FGF-1 and FGF-2 in the control of blood vessel formation is presented and their involvement in normal and pathological angiogenesis during adult life is then described in more detail.
酸性成纤维细胞生长因子（FGF-1）和碱性成纤维细胞生长因子（FGF-2）是在许多组织中都能发现的普遍存在的细胞因子。它们对源自中胚层和神经外胚层的多种细胞类型有作用，包括内皮细胞。在这篇综述中，描述了成纤维细胞生长因子家族及其受体的结构和功能。文中呈现了表明FGF-1和FGF-2都参与血管形成控制的证据，随后更详细地描述了它们在成年期正常和病理性血管生成中的作用。
