Naseem Muhammad, Kunz Meik, Dandekar Thomas
Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, Würzburg, Germany.
Bioinform Biol Insights. 2014 Feb 13;8:35-44. doi: 10.4137/BBI.S13462.. eCollection 2014.
Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein-protein interactions (PPI) are coupled to changes in cytokinin-mediated gene expression. Nodes of the cellular interactome that are enriched in immune functions also reconstitute sub-networks. Topological analyses and their specific immunological relevance lead to the identification of functional hubs in cellular interactome. We discuss our identified immune hubs in light of an emerging model of cytokinin-mediated immune defense against pathogen infection in plants.
已知涉及水杨酸（SA）、茉莉酸（JA）、乙烯（Et）以及生长素、赤霉素和脱落酸（ABA）的植物激素可调节宿主免疫反应。然而，植物激素细胞分裂素有可能调节包括SA和JA在内的防御信号传导。它能促进植物对病原体和食草动物的抗性；其潜在机制仍不清楚。我们采用系统生物学方法，揭示了拟南芥中细胞分裂素信号介导的免疫相互作用的枢纽点。高可信度的拟南芥蛋白质-蛋白质相互作用（PPI）与细胞分裂素介导的基因表达变化相关联。细胞相互作用组中富含免疫功能的节点也重新构建了子网络。拓扑分析及其特定的免疫学相关性导致在细胞相互作用组中识别出功能枢纽。我们根据细胞分裂素介导的植物对病原体感染的免疫防御新模型，讨论我们所识别出的免疫枢纽。
