Zhao Hua, Liu Kui-Jie, Lei Zhen-Dong, Lei San-Lin, Tian Yong-Quan
School of Public Health, Central South University, Changsha, China ; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
PLoS One. 2014 Feb 18;9(2):e88656. doi: 10.1371/journal.pone.0088656. eCollection 2014.
A number of studies have explored the association of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and risk of colorectal cancer; however, the results are inconsistent. We performed this meta-analysis to clarify this issue using all the available evidence. Relevant studies were retrieved by searching PubMed. Eleven case-control studies were included in the meta-analysis, representing 2909 cases and 4903 controls. The pooled results based on all included studies showed a decreased colorectal cancer risk in the analysis of the GA genotype vs. the GG genotype (OR = 0.81, 95%CI = 0.68-0.98, p = 0.03) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67-0.98, p = 0.03). However, there was no statistical difference in the AA vs. GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17). Cumulative meta-analysis based on publication time confirmed these findings. Patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02-1.20, p = 0.02) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81-0.98, p = 0.02) comparing with control population. Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.
多项研究探讨了乙醛脱氢酶-2（ALDH2）Glu487Lys多态性与结直肠癌风险之间的关联；然而，结果并不一致。我们进行了这项荟萃分析，以利用所有现有证据来阐明这一问题。通过检索PubMed获取相关研究。荟萃分析纳入了11项病例对照研究，共2909例病例和4903例对照。基于所有纳入研究的汇总结果显示，在GA基因型与GG基因型的分析中（OR = 0.81，95%CI = 0.68 - 0.98，p = 0.03）以及显性遗传模型分析中（OR = 0.81，95%CI = 0.67 - 0.98，p = 0.03），结直肠癌风险降低。然而，在AA与GG分析中（OR = 0.74，95%CI = 0.52 - 1.06，p = 0.11）以及隐性遗传模型分析中（OR = 0.86，95%CI = 0.69 - 1.07，p = 0.17），没有统计学差异。基于发表时间的累积荟萃分析证实了这些发现。与对照人群相比，结直肠癌患者的GG基因型频率较高（OR = 1.10，95%CI = 1.02 - 1.20，p = 0.02），而GA基因型频率较低（OR = 0.89，95%CI = 0.81 - 0.98，p = 0.02）。我们的结果表明，ALDH2 Glu487Lys多态性可能与结直肠癌风险降低有关。
