López-Alcaraz Fátima, Del Toro-Equihua Mario, Orta-Duarte Mariana, Flores-Ruelas Yunue, Sánchez-Ramírez Carmen Alicia
Facultad de Medicina. Universidad de Colima. Colima. México..
Nutr Hosp. 2014 Mar 1;29(3):531-6. doi: 10.3305/nh.2014.29.3.7158.
The development of chronic-degenerative diseases secondary to obesity in early infancy has alerted health providers to the importance of identifying the risk factors for obesity and assessing preventive treatment to reduce risks. Studies performed on a pediatric population have examined the role of inflammatory biomarkers (specifically CRP and TNF-α) and adiposity with inconsistent results.
To assess the relationship between the serum levels of C-reactive protein and tumor necrosis factor-alfa with adiposity measured by bioimpedance analysis in schoolchildren.
Cross sectional design. Data were collected from 74 schoolchildren randomly selected in a local primary school in the city of Colima, Mexico. The mean age was 9.4 years (1.5, SD); 33 (44.6%) were girls. The adiposity (percentage of fat mass) was measured using bioimpedance analysis and anthropometric measurements. Serum C-reactive protein and tumor necrosis factor alpha were determined with enzyme-linked immunosorbent assay. The association between adiposity and serum inflammatory biomarkers was assessed with non parametric tests (Mann Whitney and Kruskall Wallis tests), and parametric tests (Pearson's correlation).
Children with obesity had a significantly higher level of C-reactive protein [2.90 mg/L (0.07-9.37)] compared with children with a normal percentage of fat mass [0.71 mg/L (0.07-5.75)] (p < 0.001). No differences between groups were identified regarding serum levels of tumor necrosis factor-alfa. Modest correlations were identified between serum levels of C-reactive protein, adiposity determined by bioimpedance analysis (r = 0.453, p < 0.001); body mass index (r = 0.398, p = 0.001); triceps skinfold (r = 0.369, p = 0.002); and subescapular skinfold (r = 0.405, p < 0.001). No correlation was found between adiposity and serum tumor necrosis factor-alfa.
Subclinical inflammation manifested by higher serum levels of C-reactive protein was identified in schoolchildren with higher percentage of fat mass as determined by bioimpedance analysis and other anthropometric measurements.
婴儿早期肥胖继发的慢性退行性疾病的发展，已使医疗服务提供者意识到识别肥胖风险因素以及评估预防治疗以降低风险的重要性。针对儿童群体开展的研究，探讨了炎症生物标志物（特别是CRP和TNF-α）与肥胖的关系，但结果并不一致。
评估小学生血清C反应蛋白和肿瘤坏死因子-α水平与通过生物电阻抗分析测量的肥胖之间的关系。
采用横断面设计。从墨西哥科利马市一所当地小学随机选取74名小学生收集数据。平均年龄为9.4岁（标准差1.5）；33名（44.6%）为女孩。使用生物电阻抗分析和人体测量法测量肥胖程度（脂肪量百分比）。采用酶联免疫吸附测定法测定血清C反应蛋白和肿瘤坏死因子α。用非参数检验（曼-惠特尼检验和克鲁斯卡尔-沃利斯检验）以及参数检验（皮尔逊相关性检验）评估肥胖与血清炎症生物标志物之间的关联。
与脂肪量百分比正常的儿童[0.71 mg/L（0.07 - 5.75）]相比，肥胖儿童的C反应蛋白水平显著更高[2.90 mg/L（0.07 - 9.37）]（p < 0.001）。在血清肿瘤坏死因子-α水平方面，未发现各组之间存在差异。血清C反应蛋白水平与通过生物电阻抗分析测定的肥胖程度（r = 0.453，p < 0.001）、体重指数（r = 0.398，p = 0.001）、三头肌皮褶厚度（r = 0.
