Catalán Marcelo A, Peña-Munzenmayer Gaspar, Melvin James E
Secretory Mechanisms and Dysfunction Section (SMDS), National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Building 10/Room 5N102, Bethesda, MD 20892, USA.
Secretory Mechanisms and Dysfunction Section (SMDS), National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Building 10/Room 5N102, Bethesda, MD 20892, USA.
Cell Calcium. 2014 Jun;55(6):362-8. doi: 10.1016/j.ceca.2014.01.005. Epub 2014 Jan 31.
In the last 15 years, remarkable progress has been realized in identifying the genes that encode the ion-transporting proteins involved in exocrine gland function, including salivary glands. Among these proteins, Ca(2+)-dependent K(+) channels take part in key functions including membrane potential regulation, fluid movement and K(+) secretion in exocrine glands. Two K(+) channels have been identified in exocrine salivary glands: (1) a Ca(2+)-activated K(+) channel of intermediate single channel conductance encoded by the KCNN4 gene, and (2) a voltage- and Ca(2+)-dependent K(+) channel of large single channel conductance encoded by the KCNMA1 gene. This review focuses on the physiological roles of Ca(2+)-dependent K(+) channels in exocrine salivary glands. We also discuss interesting recent findings on the regulation of Ca(2+)-dependent K(+) channels by protein-protein interactions that may significantly impact exocrine gland physiology.
在过去15年里，在鉴定编码参与外分泌腺功能（包括唾液腺）的离子转运蛋白的基因方面取得了显著进展。在这些蛋白质中，钙依赖性钾通道参与了包括膜电位调节、液体流动和外分泌腺钾分泌等关键功能。在外分泌唾液腺中已鉴定出两种钾通道：（1）由KCNN4基因编码的具有中等单通道电导的钙激活钾通道，以及（2）由KCNMA1基因编码的具有大单通道电导的电压和钙依赖性钾通道。本综述重点关注钙依赖性钾通道在外分泌唾液腺中的生理作用。我们还讨论了关于钙依赖性钾通道通过蛋白质-蛋白质相互作用进行调节的有趣最新发现，这些发现可能会显著影响外分泌腺生理学。
