Visualizing Meyer's loop: A comparison of deterministic and probabilistic tractography.

BACKGROUND

Diffusion tensor tractography of the anterior extent of the optic radiation - Meyer's loop - prior to temporal lobe resection (TLR) may reduce the risk for postoperative visual field defect. Currently there is no standardized way to perform tractography.

OBJECTIVE

To visualize Meyer's loop using deterministic (DTG) and probabilistic tractography (PTG) at different probability levels, with the primary aim to explore possible differences between methods, and the secondary aim to explore anatomical accuracy.

METHODS

Twenty-three diffusion tensor imaging exams (11 controls and 7 TLR-patients, pre- and post-surgical) were analyzed using DTG and PTG thresholded at probability levels 0.2%, 0.5%, 1%, 5% and 10%. The distance from the tip of the temporal lobe to the anterior limit of Meyer's loop (TP-ML) was measured in 46 optic radiations. Differences in TP-ML between the methods were compared. Results of the control group were compared to dissection studies and to a histological atlas.

RESULTS

For controls and patients together, there were statistically significant differences (p<0.01) for TP-ML between all methods thresholded at PTG ≤1% compared to all methods thresholded at PTG ≥5% and DTG. There were no statistically significant differences between PTG 0.2%, 0.5% and 1% or between PTG 5%, 10% and DTG. For the control group, PTG ≤1% showed a closer match to dissection studies and PTG 1% showed the best match to histological tracings of Meyer's loop.

CONCLUSIONS

Choice of tractography method affected the visualized location of Meyer's loop significantly in a heterogeneous, clinically relevant study group. For the controls, PTG at probability levels ≤1% was a closer match to dissection studies. To determine the anterior extent of Meyer's loop, PTG is superior to DTG and the probability level of PTG matters.