PGC-1α 在肌肉中的多种作用——最新进展。
The many roles of PGC-1α in muscle--recent developments.
机构信息
Cardiovascular Institute and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School.
Cardiovascular Institute and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School.
出版信息
Metabolism. 2014 Apr;63(4):441-51. doi: 10.1016/j.metabol.2014.01.006. Epub 2014 Jan 17.
Abstract
Skeletal muscle is the largest organ in the body and contributes to innumerable aspects of organismal biology. Muscle dysfunction engenders numerous diseases, including diabetes, cachexia, and sarcopenia. At the same time, skeletal muscle is also the main engine of exercise, one of the most efficacious interventions for prevention and treatment of a wide variety of diseases. The transcriptional coactivator PGC-1α has emerged as a key driver of metabolic programming in skeletal muscle, both in health and in disease. We review here the many aspects of PGC-1α function in skeletal muscle, with a focus on recent developments.
摘要
骨骼肌是人体最大的器官，对机体生物学的众多方面都有贡献。肌肉功能障碍会导致许多疾病，包括糖尿病、恶病质和肌肉减少症。同时，骨骼肌也是运动的主要动力，运动是预防和治疗各种疾病最有效的干预措施之一。转录共激活因子 PGC-1α 已成为骨骼肌代谢编程的关键驱动因素，无论是在健康还是疾病状态下。我们在这里回顾了 PGC-1α 在骨骼肌中的许多功能方面，重点介绍了最近的进展。
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