Fozzard H A
Department of Medicine, University of Chicago, IL.
Am Heart J. 1988 Jul;116(1 Pt 1):230-5. doi: 10.1016/0002-8703(88)90283-9.
Cardiac contraction is a highly regulated process that involves nearly every aspect of the cardiac cell function. Many steps in the process are regulated by the cell to optimize contraction, and these can often be modified to benefit the patient with heart damage. These include the action potential, calcium channels, release and uptake of cellular calcium, sensitivity of contractile proteins to calcium, and energy utilization. A dramatic expansion of our understanding of these cellular contractile and regulatory processes gives us an unprecedented opportunity to devise new ways of modifying cardiac contraction to the benefit of our patients.
心脏收缩是一个高度受调控的过程，几乎涉及心脏细胞功能的各个方面。该过程中的许多步骤都由细胞进行调控以优化收缩，并且这些步骤通常可以被改变，从而使心脏受损的患者受益。这些方面包括动作电位、钙通道、细胞内钙的释放和摄取、收缩蛋白对钙的敏感性以及能量利用。我们对这些细胞收缩和调节过程的理解有了极大的扩展，这为我们提供了前所未有的机会来设计新方法，通过改变心脏收缩来造福我们的患者。
