Taguchi T, Horino T, Ota J
Dept. of Oncologic Surgery, Osaka University.
Gan To Kagaku Ryoho. 1988 Jul;15(7):2043-9.
TNM classification, tumor size, lymph node metastasis, histological type of primary tumor, ER status and biological tumor markers have been recognized as prognostic factors in breast cancer. The 673 breast cancer patients undergoing radical mastectomy at this department were analyzed for TNM classification influencing on the postoperative prognosis. Five-and ten- year survival rates were 93% and 89% in stage I, 83.9% and 75.5% in stage II, 67.3% and 60% in stage III. The most common histological type, namely, invasive ductal carcinoma, of primary breast cancer was classified into three types by Japan Mammary Cancer Society. The first type was papillotubular carcinoma, the second solid-tubular carcinoma, and the third scirrhous carcinoma. The prognosis of papillotubular carcinoma was best. Many investigators reported that the prognosis of ER positive breast cancer was good. But in the latest report, the opposite result is obtained. More study is necessary to evaluate the prognostic value of ER. The most common biological tumor markers were CEA, LDH and ALP. The CEA was the best prognosis-factor in biological tumor markers.
TNM分期、肿瘤大小、淋巴结转移、原发肿瘤的组织学类型、雌激素受体（ER）状态以及生物肿瘤标志物已被公认为乳腺癌的预后因素。对该科室673例行根治性乳房切除术的乳腺癌患者进行了TNM分期对术后预后影响的分析。Ⅰ期患者的5年和10年生存率分别为93%和89%，Ⅱ期分别为83.9%和75.5%，Ⅲ期分别为67.3%和60%。原发性乳腺癌最常见的组织学类型即浸润性导管癌，日本乳腺癌协会将其分为三种类型。第一种是乳头管状癌，第二种是实体管状癌，第三种是硬癌。乳头管状癌的预后最佳。许多研究者报告称ER阳性乳腺癌的预后良好。但在最新报告中，却得到了相反的结果。需要更多研究来评估ER的预后价值。最常见的生物肿瘤标志物是癌胚抗原（CEA）、乳酸脱氢酶（LDH）和碱性磷酸酶（ALP）。在生物肿瘤标志物中，CEA是最佳的预后因素。
