Morita Yoshihiro, Morita Nobuo, Hata Kenji, Nakanishi Masako, Kimoto Natsuko, Omata Tetsuji, Nakamura Yasushi, Yoneda Toshiyuki
Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan; Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, Osaka, Japan; Department of Oral and Maxillofacial Surgery, Seichokai Hannan City Hospital, Hannan, Japan.
Department of Oral and Maxillofacial Surgery, Social Insurance Kinan Hospital, Tanabe, Japan; Department of Oral and Maxillofacial Surgery, Wakayama Wellness Foundation, Wakayama, Japan; Department of Oral and Maxillofacial Surgery, Seichokai Hannan City Hospital, Hannan, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Apr;117(4):502-10. doi: 10.1016/j.oooo.2013.12.410. Epub 2013 Dec 28.
This study aimed to determine the relationship of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-c (VEGF-C) expression with lymphangiogenesis, lymph node metastasis (LNM), and other clinicopathologic features in human oral tongue cancers.
Forty tongue cancer specimens were immunohistochemically examined for COX-2 and VEGF-C expression and for lymphatic vessel density (LVD). We analyzed the relationships between COX-2 and VEGF-C expression and the relationships of such expression with clinicopathologic findings and survival of patients.
Eighteen tumors out of 40 (45%) showed COX-2 expression, and 18 tumors (45%) expressed VEGF-C. Twelve tumors (30%) coexpressed COX-2/VEGF-C. A significant correlation was found between COX-2 and VEGF-C expression (P < .01). Of note, COX-2/VEGF-C coexpression significantly correlated with lymphangiogenesis, LNM, TNM stage (P < .01), and LVD (P < .05). In Cox regression for survival, COX-2/VEGF-C coexpression was identified as an independent prognostic factor (P < .05).
Our results suggest that examination of immunohistochemical expression of COX-2 and VEGF-C predicts LNM and survival in human oral tongue cancers.
本研究旨在确定环氧化酶-2（COX-2）和血管内皮生长因子-C（VEGF-C）的表达与人类口腔舌癌淋巴管生成、淋巴结转移（LNM）及其他临床病理特征之间的关系。
对40例舌癌标本进行免疫组织化学检查，以检测COX-2和VEGF-C的表达以及淋巴管密度（LVD）。我们分析了COX-2和VEGF-C表达之间的关系，以及这种表达与临床病理结果和患者生存率之间的关系。
40例肿瘤中有18例（45%）显示COX-2表达，18例肿瘤（45%）表达VEGF-C。12例肿瘤（30%）共表达COX-2/VEGF-C。COX-2和VEGF-C表达之间存在显著相关性（P < 0.01）。值得注意的是，COX-2/VEGF-C共表达与淋巴管生成、LNM、TNM分期（P < 0.01）和LVD（P < 0.05）显著相关。在生存的Cox回归分析中，COX-2/VEGF-C共表达被确定为独立的预后因素（P < 0.05）。
我们的结果表明，检测COX-2和VEGF-C的免疫组织化学表达可预测人类口腔舌癌的LNM和生存率。
