Popoli P, Pèzzola A, Scotti de Carolis A
Laboratorio di Farmacologia, Istituto Superiore di Sanità, Rome, Italy.
Arch Int Pharmacodyn Ther. 1988 Mar-Apr;292:58-67.
The present work deals with an EEG and behavioral study on the effects of the calcium antagonist nimodipine against the convulsions due to pentylenetetrazole (PTZ) in rats and rabbits. In rats, nimodipine (0.25-1 mg/kg i.p. 15 min before) has a dose-dependent protective effect against PTZ-induced seizures (50 mg/kg i.p.). This effect was reverted by the calcium channel activator BAY K 8644 (1-2 mg/kg, i.p.) showing that the anticonvulsant properties of nimodipine depend upon its calcium antagonistic activity. In rabbits, nimodipine (0.05-4 mg/kg i.v. 5 min before) did not prevent the seizures induced by PTZ (20 mg/kg i.v.). However, the lowest dose of nimodipine (0.05 mg/kg i.v.) was able to prevent or suppress the spike-and-wave complexes elicited by PTZ (10 mg/kg i.v.). These results suggest that the modulation of the calcium influx in the CNS might influence the epileptic phenomena.
本研究探讨了钙拮抗剂尼莫地平对大鼠和家兔因戊四氮（PTZ）诱发惊厥的脑电图及行为学影响。在大鼠中，尼莫地平（腹腔注射，剂量为0.25 - 1mg/kg，于前15分钟给药）对PTZ诱导的癫痫发作（腹腔注射剂量为50mg/kg）具有剂量依赖性保护作用。钙通道激活剂BAY K 8644（腹腔注射，剂量为1 - 2mg/kg）可逆转此效应，表明尼莫地平的抗惊厥特性取决于其钙拮抗活性。在家兔中，尼莫地平（静脉注射，剂量为0.05 - 4mg/kg，于前5分钟给药）不能预防PTZ（静脉注射剂量为20mg/kg）诱发的癫痫发作。然而，最低剂量的尼莫地平（静脉注射剂量为0.05mg/kg）能够预防或抑制PTZ（静脉注射剂量为10mg/kg）诱发的棘波和慢波复合波。这些结果表明，中枢神经系统中钙内流的调节可能会影响癫痫现象。
