Popoli P, Pèzzola A, Scotti de Carolis A
Pharmacology Department, Istituto Superiore di Sanità, Roma, Italy.
Arch Int Pharmacodyn Ther. 1990 Jul-Aug;306:45-56.
The present work deals with an EEG and behavioral study on the effects of the calcium antagonist flunarizine against the convulsions due to pentylenetetrazole in rats. Flunarizine (1.5-18 mg/kg, i.p.) has a dose-dependent protective effect against pentylenetetrazole-induced seizures (50 mg/kg, i.p.). Tonic seizures were primarily affected by flunarizine. N6-L-phenylisopropyl-adenosine (an A1 adenosine receptor agonist) potentiated the anticonvulsant effects of flunarizine at the dose of 0.05 mg/kg, i.p. Conversely, caffeine (10 and 50 mg/kg, i.p.) reverted the antiepileptic activity of flunarizine in a dose-related way. These results confirm some previous reports on the anticonvulsant effects of flunarizine in various experimental models. They also suggest that some interesting interactions may exist between flunarizine and the adenosine system.
本研究探讨了钙拮抗剂氟桂利嗪对大鼠戊四氮惊厥影响的脑电图及行为学研究。氟桂利嗪（1.5 - 18毫克/千克，腹腔注射）对戊四氮诱导的惊厥（50毫克/千克，腹腔注射）具有剂量依赖性保护作用。强直惊厥主要受氟桂利嗪影响。N6-L-苯异丙基腺苷（一种A1腺苷受体激动剂）在0.05毫克/千克腹腔注射剂量时增强了氟桂利嗪的抗惊厥作用。相反，咖啡因（10和50毫克/千克，腹腔注射）以剂量相关方式逆转了氟桂利嗪的抗癫痫活性。这些结果证实了先前关于氟桂利嗪在各种实验模型中抗惊厥作用的一些报道。它们还表明氟桂利嗪与腺苷系统之间可能存在一些有趣的相互作用。
