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人眼外肌单型和多型终板间乙酰胆碱受体的抗原性差异

Antigenic difference of acetylcholine receptor between single and multiple form endplates of human extraocular muscle.

作者信息

Oda K, Shibasaki H

机构信息

Department of Internal Medicine, Saga Medical School, Japan.

出版信息

Brain Res. 1988 May 24;449(1-2):337-40. doi: 10.1016/0006-8993(88)91049-9.

DOI:10.1016/0006-8993(88)91049-9
PMID:2456129
Abstract

The acetylcholine receptor (AChR) of human extraocular muscle (EOM) has been studied by the immunological method using anti-AChR antibodies obtained from the sera of patients with myasthenia gravis (MG) of ocular type, whose symptoms have been restricted to EOM. Those antibodies could distinguish the AChR of multiple (en grappe) form endplates from that of single (en plaque) form endplates. This result indicates the antigenic difference of AChR between those two forms of endplates of human EOM.

摘要

利用从眼型重症肌无力（MG）患者血清中获得的抗乙酰胆碱受体（AChR）抗体，通过免疫学法对人眼外肌（EOM）的AChR进行了研究，这些患者的症状局限于眼外肌。这些抗体能够区分多突触（丛状）终板型AChR和单突触（板状）终板型AChR。这一结果表明人眼外肌这两种终板形式的AChR存在抗原差异。

相似文献

1
Antigenic difference of acetylcholine receptor between single and multiple form endplates of human extraocular muscle.人眼外肌单型和多型终板间乙酰胆碱受体的抗原性差异
Brain Res. 1988 May 24;449(1-2):337-40. doi: 10.1016/0006-8993(88)91049-9.
2
Myasthenia gravis without acetylcholine-receptor antibody: a distinct disease entity.无乙酰胆碱受体抗体的重症肌无力：一种独特的疾病实体。
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Antibodies to motor endplates demonstrated with the immunofluorescence technique.采用免疫荧光技术显示运动终板抗体。
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Experimental myasthenia: lack of correlation between the autoantibody titer and the reduction of acetylcholine-controlled ionic channels measured at functioning endplates.
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Expression of acetylcholine receptor isoforms at extraocular muscle endplates.眼外肌终板处乙酰胆碱受体亚型的表达
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Autoantibodies in myasthenia gravis: demonstration of anti-motor endplate antibody and anti-muscle membrane antibody using membrane immunofluorescence technique.重症肌无力中的自身抗体：运用膜免疫荧光技术证实抗运动终板抗体和抗肌膜抗体
Acta Med Okayama. 1975 Dec;29(6):397-404.
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[The evidence of antibodies against motor endplates of the skeletal muscle in myasthenia gravis with the double immune-fluorescence technique (author's transl)].用双重免疫荧光技术检测重症肌无力患者骨骼肌运动终板抗体的证据（作者译）
Acta Histochem. 1981;69(1):18-22.
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A postnatal change in the immunological properties of the acetylcholine receptor at rat muscle endplates.大鼠肌肉终板处乙酰胆碱受体免疫特性的产后变化。
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Differences in acetylcholine receptor-antibody interactions between extraocular and extremity muscle fibers.眼外肌纤维与肢体肌纤维之间乙酰胆碱受体 - 抗体相互作用的差异。
Ann N Y Acad Sci. 1993 Jun 21;681:238-55. doi: 10.1111/j.1749-6632.1993.tb22889.x.
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Anti-acetylcholine receptor antibodies.抗乙酰胆碱受体抗体
J Neurol Neurosurg Psychiatry. 1980 Jul;43(7):590-600. doi: 10.1136/jnnp.43.7.590.

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