From the *Specialised PET Services Queensland, †Helix Pathology, and ‡Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Herston; and §School of Medicine, University of Queensland, St. Lucia, Australia.
Clin Nucl Med. 2014 Sep;39(9):828-30. doi: 10.1097/RLU.0000000000000378.
A previously well 48-year-old male patient presented with several months of weight loss, fever, massive hepatosplenomegaly, and pancytopenia. A provisional diagnosis of lymphoma could not be confirmed on blind lymph node or bone marrow biopsies. Referral for 18F-FDG PET was made to identify an appropriate biopsy site. Focal uptake in multiple splenic lesions was seen, with normal FDG uptake elsewhere in the body. Splenectomy was then performed and histology revealed leishmaniasis, with no evidence of lymphoma. Focally FDG avid splenic deposits have never been reported in leishmaniasis and were likely due to nodular red pulp expansion.
一位之前身体状况良好的 48 岁男性患者出现数月的体重减轻、发热、巨脾和全血细胞减少。在进行盲法淋巴结或骨髓活检时，无法确诊为淋巴瘤。因此进行了 18F-FDG PET 检查以确定合适的活检部位。检查发现多个脾脏病变部位有局灶性摄取，而全身其他部位的 FDG 摄取正常。随后进行了脾切除术，组织学检查显示为利什曼病，无淋巴瘤证据。在利什曼病中从未报道过局灶性 FDG 摄取的脾脏沉积物，可能是由于结节性红髓扩张所致。
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