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输入性内脏利什曼病——一名发热、全血细胞减少和脾肿大患者的意外骨髓诊断结果

Imported visceral leishmaniasis - unexpected bone marrow diagnosis in a patient with fever, pancytopenia, and splenomegaly.

作者信息

Gallina Valentina, Binazzi Raffaella, Golemi Arber, Farsad Mohsen, Weiss Günter, Wiedermann Christian J

机构信息

Department of Internal Medicine, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.

Department of Infectious Disease, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.

出版信息

Am J Blood Res. 2014 Dec 15;4(2):101-5. eCollection 2014.

Abstract

Leishmaniasis is spreading from mediterranean countries to the north of Europe. The Alps are not an endemic region and there are only few reports of sporadic cases. We report the case of a 72 year old male who presented after a syncope with fever, cough and a sacral skin rash. Clinical examination revealed splenomegaly, elevated liver enzymes and pancytopenia; differential diagnosis included myeloproliferative or lymphoproliferative disorders, infections and auto-immune conditions that cause enlargement of the spleen and liver diseases, however, all tests were negative. In (18)FDG PET computerized tomography, pathological and diffuse uptake in the spleen was seen, with mild and homogeneous FDG uptake in the bone marrow and normal tracer uptake elsewhere in the body. Bone marrow aspiration revealed the presence of numerous intra- and extracellular Leishmania amastigotes. Travel history indicated that he had been in Sardinia for a 7-day vacation several months ago. The patient promptly responded to treatment with liposomal amphotericin B. Imported visceral leishmaniasis is likely to be seen more frequently in non-endemic regions and fever, pancytopenia and splenomegaly are diagnostic clues, whereas diagnostic confirmation may be done by detection of Leishmania spp. amastigotes in the bone marrow.

摘要

利什曼病正从地中海国家蔓延至欧洲北部。阿尔卑斯地区并非该病的流行区域,仅有少数散发病例的报告。我们报告一例72岁男性病例,该患者在晕厥后出现发热、咳嗽及骶部皮疹。临床检查发现脾肿大、肝酶升高及全血细胞减少;鉴别诊断包括骨髓增殖性或淋巴增殖性疾病、感染以及导致脾肿大的自身免疫性疾病和肝脏疾病,然而,所有检查结果均为阴性。在(18)氟代脱氧葡萄糖正电子发射断层扫描计算机断层成像中,可见脾脏有病理及弥漫性摄取,骨髓有轻度且均匀的氟代脱氧葡萄糖摄取,身体其他部位示踪剂摄取正常。骨髓穿刺显示存在大量细胞内和细胞外利什曼原虫无鞭毛体。旅行史表明他几个月前在撒丁岛度过了7天假期。该患者对脂质体两性霉素B治疗反应迅速。输入性内脏利什曼病在非流行地区可能更常见,发热、全血细胞减少和脾肿大是诊断线索,而诊断的确立可通过在骨髓中检测到利什曼原虫无鞭毛体来完成。

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