代谢综合征群组与细胞膜小窝的关联。
An association of metabolic syndrome constellation with cellular membrane caveolae.
作者信息
Zhang Wei-Zheng
机构信息
CMP Laboratory, Port Melbourne, Melbourne, Victoria, Australia.
出版信息
Pathobiol Aging Age Relat Dis. 2014 Feb 12;4. doi: 10.3402/pba.v4.23866. eCollection 2014.
Abstract
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that can predispose an individual to a greater risk of developing type-2 diabetes and cardiovascular diseases. The cluster includes abdominal obesity, dyslipidemia, hypertension, and hyperglycemia - all of which are risk factors to public health. While searching for a link among the aforementioned malaises, clues have been focused on the cell membrane domain caveolae, wherein the MetS-associated active molecules are colocalized and interacted with to carry out designated biological activities. Caveola disarray could induce all of those individual metabolic abnormalities to be present in animal models and humans, providing a new target for therapeutic strategy in the management of MetS.
摘要
代谢综合征（MetS）是一组代谢异常，会使个体更易患2型糖尿病和心血管疾病。该综合征包括腹部肥胖、血脂异常、高血压和高血糖——所有这些都是公共健康的危险因素。在寻找上述不适之间的联系时，线索集中在细胞膜区域小窝，其中与代谢综合征相关的活性分子共定位并相互作用以进行特定的生物学活动。小窝紊乱可导致动物模型和人类出现所有这些个体代谢异常，为代谢综合征管理中的治疗策略提供了新靶点。
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