U.O.C. Medicina Vascolare, Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), University of Palermo, Palermo, Italy.
Int J Clin Pract. 2013 Dec;67(12):1247-53. doi: 10.1111/ijcp.12269.
Regular exercise demonstrated the ability to provide enormous benefits to many diseases, atherosclerotic-based, degenerative and neoplastic, but also to grant anti-inflammatory actions, assessed by various authors in different populations. Despite of these clear benefits, many patients are unable to attain long-term results through chronic physical activity for different causes. On this basis, the aim of our study was to assess the metabolic and anti-inflammatory effects of a home-based programme of fast walking in patients affected by metabolic syndrome (MS).
We enrolled 176 subjects with MS as stated by ATP III criteria. Patients were invited to walk for 1 h every day 5 days a week for 24 weeks. The walking velocity was required higher than the one retained 'comfortable' by the patient, previously assessed in the run-in visit. Monitoring of physical activity was carried out through an OMRON step counter type Walking Style II. All the subjects enrolled completed the training period.
After the 24 weeks of intervention body mass index changed from 31.59 to 29.23 (p < 0.001); mean waist circumference passed from 105.19 to 100.06 cm (p < 0.001); mean fasting glucose changed from 119.76 to 114.32 mg/dl (p < 0.001); for diabetic population (n = 70) mean glicated haemoglobin levels changed from 7.38% to 6.86% (p < 0.001); total cholesterol levels from 192.15 to 185.78 mg/dl (p < 0.001); HDL cholesterol levels raised from 44.03 to 47.63 mg/dl (p < 0.001); triglycerides levels lowered from 148.29 to 135.20 mg/dl (p < 0.001); WBC changed from 7361.08 to 7022.56/mm(3) (p < 0.001); hs-CRP from 0.55 to 0.28 mg/dl (p < 0.001); fibrinogen serum levels lowered from 339.68 to 314.86 mg/dl (p < 0.001).
A long-term home-based programme of aerobic physical activity improves metabolic asset and reduces systemic inflammation in sedentary people.
有规律的运动被证明对许多疾病，如基于动脉粥样硬化的、退行性的和肿瘤性疾病，具有巨大益处，同时还具有抗炎作用，这已被不同作者在不同人群中评估。尽管有这些明显的益处，但许多患者由于各种原因无法通过长期的身体活动达到长期效果。基于此，我们的研究目的是评估代谢综合征（MS）患者进行家庭快速步行计划的代谢和抗炎效果。
我们招募了 176 名符合 ATP III 标准的 MS 患者。患者被邀请每天步行 1 小时，每周 5 天，持续 24 周。步行速度要求高于患者在预试验中评估的“舒适”速度。通过欧姆龙计步器类型 Walking Style II 监测身体活动。所有入组的受试者均完成了训练期。
干预 24 周后，体重指数从 31.59 降至 29.23（p<0.001）；平均腰围从 105.19 降至 100.06cm（p<0.001）；空腹血糖从 119.76 降至 114.32mg/dl（p<0.001）；对于糖尿病患者（n=70），糖化血红蛋白水平从 7.38%降至 6.86%（p<0.001）；总胆固醇水平从 192.15 降至 185.78mg/dl（p<0.001）；高密度脂蛋白胆固醇水平从 44.03 升至 47.63mg/dl（p<0.001）；甘油三酯水平从 148.29 降至 135.20mg/dl（p<0.001）；白细胞计数从 7361.08 降至 7022.56/mm3（p<0.001）；hs-CRP 从 0.55 降至 0.28mg/dl（p<0.001）；血清纤维蛋白原水平从 339.68 降至 314.86mg/dl（p<0.001）。
长期家庭有氧运动计划可改善久坐人群的代谢指标，并降低全身炎症。
