Gaillard Trudy
Division of Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, 541 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210, USA.
J Clin Med. 2014 Aug 13;3(3):897-912. doi: 10.3390/jcm3030897.
The metabolic syndrome (MetS) is a constellation of risk factors that are associated with increased risks for coronary heart disease and type 2 diabetes. Although the cause is unknown, abdominal adiposity is considered the underpinning of these metabolic alterations. Hence, increased abdominal adiposity contributes to dyslipidemia, hyperglycemia, beta cell dysfunction, insulin resistance, hypertension and inflammation. The role of abdominal adiposity in the causation of metabolic alterations that lead to the clinical expression of the MetS has become a focus of active research. In addition, there are ethnic/racial differences in the manifestation of the MetS. Therefore, the focus of this current review is to: (1) explore the consequences of abdominal obesity within the MetS paradigm; and (2) discuss the impact of ethnicity/race on MetS in Black People of African Ancestry (PAA).
代谢综合征（MetS）是一组与冠心病和2型糖尿病风险增加相关的危险因素。尽管病因不明，但腹部肥胖被认为是这些代谢改变的基础。因此，腹部肥胖增加会导致血脂异常、高血糖、β细胞功能障碍、胰岛素抵抗、高血压和炎症。腹部肥胖在导致代谢综合征临床症状的代谢改变病因中的作用已成为积极研究的焦点。此外，代谢综合征的表现存在种族差异。因此，本综述的重点是：（1）在代谢综合征范式内探讨腹部肥胖的后果；（2）讨论种族对非洲裔黑人（PAA）代谢综合征的影响。
