Nomori H, Kaseda S, Kobayashi K, Ishihara T, Yanai N, Torikata C
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
J Thorac Cardiovasc Surg. 1988 Aug;96(2):271-7.
Twelve cases of adenoid cystic carcinoma of the trachea and main-stem bronchus were histologically analyzed, and the results were examined with reference to the growth pattern of the tumor and the prognosis. The tumors were histologically classified into tubular, cribriform, and solid subtypes. Three histologic grades were established: grade I, tumors with tubular and cribriform subtypes but without solid subtype; grade II, tumors with tubular and cribriform subtypes in which the solid subtype comprised less than 20% of the area; grade III, tumors in which the solid subtype comprised more than 20% of the area. Three gross infiltrating types were established: type I, entirely intraluminal; type II, predominantly intraluminal; type III, predominantly extraluminal. In most cases histologic grade correlated with gross tumor type; that is, grades, I, II, and III were grossly types I, II, and III, respectively. The tumors infiltrating along the tracheobronchial wall were of the tubular or cribriform subtype, but not of the solid subtype. In two patients who died of distant metastasis, the histologic studies revealed the solid subtype. Immunohistochemical analysis demonstrated that the tubular subtype was the most differentiated form and the solid subtype, the most undifferentiated form. The histologic subtype of adenoid cystic carcinoma of the tracheobronchial tree was an important factor in the growth pattern of the tumor and the prognosis.
对12例气管及主支气管腺样囊性癌进行了组织学分析，并根据肿瘤的生长模式和预后对结果进行了检查。肿瘤在组织学上分为管状、筛状和实体亚型。确定了三个组织学分级：I级，具有管状和筛状亚型但无实体亚型的肿瘤；II级，具有管状和筛状亚型且实体亚型占面积小于20%的肿瘤；III级，实体亚型占面积超过20%的肿瘤。确定了三种大体浸润类型：I型，完全腔内型；II型，主要腔内型；III型，主要腔外型。在大多数情况下，组织学分级与大体肿瘤类型相关；即I、II和III级分别为大体I、II和III型。沿气管支气管壁浸润的肿瘤为管状或筛状亚型，但不是实体亚型。在两名死于远处转移的患者中，组织学研究显示为实体亚型。免疫组织化学分析表明，管状亚型是分化程度最高的形式，而实体亚型是分化程度最低的形式。气管支气管树腺样囊性癌的组织学亚型是肿瘤生长模式和预后的重要因素。
