Das Jai K, Lassi Zohra S, Salam Rehana A, Bhutta Zulfiqar A
BMC Public Health. 2013;13 Suppl 3(Suppl 3):S29. doi: 10.1186/1471-2458-13-S3-S29. Epub 2013 Sep 17.
Diarrhea and pneumonia are the two leading causes of mortality in children under five. Improvements have occurred over the past two decades but the progress is slow to meet the MDG-4.
We conducted a systematic review of the randomized controlled trials, quasi-experimental and observational studies to estimate the effect of community based interventions including community case management on the coverage of various commodities and on mortality due to diarrhea and pneumonia. We used a standardized abstraction and grading format and performed meta-analyses for all the relevant outcomes. The estimated effect of community based interventions was determined by applying the standard Child Health Epidemiology Reference Group (CHERG) rules.
We included twenty four studies in this review. Community based interventions led to significant rise in care seeking behaviors with 13% and 9% increase in care seeking for pneumonia and diarrhea respectively. These interventions were associated with 160% increase in the use of ORS and 80% increase in the use of zinc for diarrhea. There was a 75% decline in the unnecessary use of antibiotics for diarrhea and a 40% decrease in treatment failure rates for pneumonia. Community case management for diarrhea and pneumonia is associated with a 32% reduction in pneumonia specific mortality, while the evidence on diarrhea related mortality is weak.
Community based interventions have the potential to scale up care seeking and the use of essential commodities and significantly decrease morbidity and mortality burden due to diarrhea and pneumonia in children under the age of five years.
腹泻和肺炎是五岁以下儿童死亡的两大主要原因。在过去二十年中虽有改善,但进展缓慢,难以实现千年发展目标4。
我们对随机对照试验、准实验和观察性研究进行了系统评价,以评估包括社区病例管理在内的社区干预措施对各种用品的覆盖率以及对腹泻和肺炎所致死亡率的影响。我们采用标准化的摘要和分级格式,并对所有相关结果进行荟萃分析。基于社区的干预措施的估计效果通过应用标准的儿童健康流行病学参考组(CHERG)规则来确定。
我们在本评价中纳入了24项研究。基于社区的干预措施导致就医行为显著增加,肺炎和腹泻的就医率分别提高了13%和9%。这些干预措施使腹泻时口服补液盐(ORS)的使用增加了160%,锌的使用增加了80%。腹泻时抗生素的不必要使用减少了75%,肺炎的治疗失败率降低了40%。腹泻和肺炎的社区病例管理与肺炎特异性死亡率降低32%相关,而关于腹泻相关死亡率的证据不足。
基于社区的干预措施有可能扩大就医范围和基本用品的使用,并显著降低五岁以下儿童因腹泻和肺炎所致的发病和死亡负担。