Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Expert Rev Clin Immunol. 2014 Apr;10(4):425-7. doi: 10.1586/1744666X.2014.891440. Epub 2014 Feb 25.
Concepts regarding what causes dryness in Sjögren's syndrome have evolved over the past decade. Inflammation in the lacrimal functional unit contributes to development of dry eye by causing dysfunction and even death of tear secreting epithelium in the lacrimal gland and conjunctiva that alters tear composition and stability. Disease-relevant inflammatory mediators have been identified and therapies targeting these mediators are beginning to emerge.
过去十年中，人们对干燥综合征发病原因的认识不断发展。泪液功能单位的炎症通过导致泪腺和结膜产生泪液的上皮细胞功能障碍甚至死亡，改变泪液成分和稳定性，进而导致干眼的发生。目前已发现与疾病相关的炎症介质，针对这些介质的治疗方法也开始出现。
